The Great Lakes Chromosome Conference 2012 The role of FLT3 in sole trisomy 8 acute myeloid leukemia
نویسندگان
چکیده
FLT3 (fms-related tyrosine kinase 3) with tandem internal duplication (ITD) is a known adverse prognostic factor in normal karyotype acute myeloid leukemia (AML). Since we recently observed several patients with trisomy 8 (+8) and FLT3 positivity, we asked whether FLTD ITD carried any prognostic significance in sole trisomy 8. Trisomy 8 is the most frequent numerical aberration in AML, occurring in 5% of cytogenetically abnormal AML as the sole chromosome change. The prognostic impact of +8 as a sole aberration remains unclear and may be classified either within intermediateor highrisk groups.
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